Monoamino oxidase A (MAOA)
| Variant | Association | Phenotype | Sample Information | Author |
|---|---|---|---|---|
uVNTR |
Allelic: ns |
Suicide attempts | Cases: 270 schizophrenic patients: 92 (F:24) suicide attempters (mean age: 42.6±9.7) and 178 nonattempters (mean age: 40.6±11.2) |
De Luca, 2006 |
Notes: Investigated one MAO and three COMT; also stratified by sex and violence of suicide attempt |
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uVNTR
|
Allelic: ns |
Violent suicide attempts |
Ethnicity: West European, Caucasian |
|
Hospitalized suicide attempters: F:512; M:226; mean age: 38.08 ± 14.12 |
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| CAn | Allelic: ns |
Suicide attempts | Non-psychiatric controls without first-degree family history of suicide attempts: F:68, M:154; mean age: 44.25±13.26 | |
| Notes: CAn is in LD with uVNTR | ||||
uVNTR T941G |
Allelic: ns Haplotypic: ns Epistasis with COMT: ns |
Suicide attempts | Sample: 336 bipolar patients (F:62%) including 86 suicide attempters; mean age:35.36±10.37 |
De Luca, 2005 |
| Notes: analyses based on TDT; No epistasis with COMT Val108/158 Met | ||||
uVNTR |
Allelic: ns |
Suicide attempts | Ethnicity: white Caucasian, Italian |
Gerra, 2004 |
| Heroin –dependent males: n:104; mean age: 33.7±12.3 |
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| Age- and sex-matched healthy volunteers: n:95; mean age: 35.7±13.9 | ||||
| Notes: this variant confers increased susceptibility to antisocial violent behavior and aggressiveness in heroin-dependent males | ||||
uVNTR |
Allelic: ns |
Suicide attempts | Cases: mood-disordered patients: F:377, M:286; mean age: 37.6 ±12.9; Caucasian: 68.8%; African-Americans 16.6%; Asian, Hispanic and ‘’other" 14.6% |
Huang, 2004 |
| Nonpsychiatric controls with comparable ethnic composition: F:47, M:56; mean age: 38.8 ±15.3 | ||||
| Notes: lower expression allele associated with history of child abuse before 15 years of age and higher impulsivity in males | ||||
CAn |
ns |
Suicide attempts | Ethnicity: English, Caucasian |
Ho, 2000 |
| VNTR | Genotypic: +, VNTR, ,p=0.029, bipolar patients |
Cases: bipolar (M:58, F: 73) and unipolar patients (M:53, F: 86) | ||
| Fnu4HI | Genotypic:+, 11, p=0.0162, female bipolar patients | Notes: VNTR’s association with suicide attempts stronger in females; uncorrected for multiple testing | ||
VNTR |
Allelic: ns Genotypic: ns |
Suicide attempts | Ethnicity: Japanese |
Kunugi, 1999 |
| Patients with bipolar disorder (M:59, F:102; mean age: 47.6±13.7) or unipolar (F:61, M:37; mean age: 54.5±16.4), including 55 suicide attempters | ||||
| Controls: M:132; F:126 mean age: 31.8.6±12.3 | ||||
| Notes: no association with mood disorders | ||||
| EcoRV | Allelic: +,high-activity allele, OR:3.1, 95% CI 1.3-7.5, males |
Suicide | Ethnicity: Caucasian, Hungary |
Du, 2002 |
| Depressed suicide completers: F:11; M:33 mean age: 47.9±14.4 | ||||
| Controls who died of non-suicide-related causes: F:28; M:64 mean age: 57.5±13.6 | ||||
| Notes: Bonferroni-corrected | ||||
| uVNTR | Allelic: ns Genotypic: ns |
Suicide | Ethnicity: Japanese |
Ono, 2002 |
| Cases: suicides [M: 107; mean age: 48.4 ±16.6; F: 48; mean age: 47.6± 19.9] | ||||
| Healthy volunteers [M: 109; mean age: 45.1± 15.3; F: 53; mean age: 48.4±18.8] |
Notes: += positive, significant; - =negative,significant; ns= nonsignificant; F=females; M=males